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The Caloosahatchee River is a river on the southwest Gulf Coast of Florida in the United States, approximately 75 mi (121 km long). It drains rural area on the northern edge of the Everglades northwest of Miami. An important link in the inland waterway system of southern Florida, the river forms a tidal estuary along most of its course and has recently become the subject of efforts to restore and preserve the Everglades.